22's would look NICE on an endeavor.....BUT....it's a no go. You would need a VERY low pro tire, probably a "30" so that you would not rub against the coil by your front tires. Every shop we went to said a "30" or even "35" would not be recommended for the SUV because the SUV is just too heavy.
I have a 35-series on my Mustang. (with 20" rims)
So.....we have 20" rims on our Endeavor with a 45-series tire. It has the exact same overall wheel dimensions as a stock wheel. (Just a lot more rim, lot less tire)
The suspension on the Endeavor is car-based, which is why you have a very smooth, cushy ride. But that's an obstacle when wanting to go BIG with your rims, because it's just in the way.